Amniocentesis en gestantes con fetos con restricción del crecimiento intrauterino precoz:

estudio descriptivo

Authors

  • Lucía Vilas Saura Servicio de Obstetricia y Ginecología, Hospital San Pedro de Logroño Author
  • Sara Arrieta Bretón Servicio de Obstetricia y Ginecología, Hospital San Pedro de Logroño Author
  • José Félix García Fernández Servicio de Obstetricia y Ginecología, Hospital San Pedro de Logroño Author
  • Marta Isabel Giménez Campos Servicio de Obstetricia y Ginecología, Hospital San Pedro de Logroño Author
  • Ana Cristina Ruiz Peña Servicio de Obstetricia y Ginecología, Hospital San Pedro de Logroño Author
  • Mariano Laguna Olmos Servicio de Obstetricia y Ginecología, Hospital San Pedro de Logroño Author
  • Edurne Álvarez Suberviola Servicio de Obstetricia y Ginecología, Hospital San Pedro de Logroño Author

DOI:

https://doi.org/10.66737/ier.zub.185

Keywords:

Fetal growth retardation, amniocentesis, pregnancy outcome, child development psychomotor performance, child development, psychomotor performance

Abstract

OBJECTIVE- Intrauterine growth restriction is one of the main challenges
of perinatal management. After the diagnosis of early intrauterine
growth restriction, a protocol is established to identify causes; including per-forming an amniocentesis. The objective of this study is describe the clinical-epidemiological characteristics and the information obtained through amniocentesis in the study of fetuses with early intrauterine growth restriction. Analyze the perinatal result, weight-growth stature and psychomotor development during the lactating period. MATERIALS AND METHODS- This study is observational, descriptive and retrospective study. 580 amniocentesis performed between January 2015 and December 2019 were collected at the San Pedro Hospital (Logroño). A sample of 21 patients who had undergone this test was selected within the study protocol. RESULTS- 21 pregnancies (3.62% of total amniocentesis) were studied, with 18 live newborns. Genetic
alterations were observed in 9.52% of the amniotic fluid samples. There was no case of intramniotic infection. 33.33% of the neonates presented morbidity. A weight and/or length <P3 was recorded at 62.50%. Slowed psychomotor development was described in 18.75% of infants. CONCLUSIONS- Age over 35 years and smoking habits were related to intrauterine growth restriction, but not low body mass index or preeclampsia, whose frequency was lower than expected. Perinatal mortality was higher than the mortality rate in the general population.

Downloads

Download data is not yet available.

References

Royal College of Obstetricians and Gynaecologists (2013). The Investigation and Management of the Small for Gestational Age Fetus. Green-top Guideline No. 31.

Figueras, F.; Gratacós, E. (2014). “Update on the Diagnosis and Classification of Fetal Growth Restriction and Proposal of a Stage-Based Management Protocol”. Fetal Diagnosis and Therapy, 36(2), 86-98.

Bamberg, C.; Kalache, K.D.; Kadar, N.; Bellotti, M.; Morabito, A.; Pardi, G.; et al. (2004). “Prenatal diagnosis of fetal growth restriction”. Seminars in Fetal and Neonatal Medicine, 9(5), 387-394.

Ott, W.J. (2000). “Intrauterine growth restriction and Doppler ultrasonography”. Journal of Ultrasound in Medicine, 19(10), 661-665.

Miller, J.; Turan, S.; Baschat, A.A. (2008). “Fetal Growth Restriction”. Seminars in Perinatology, 32(4), 274-280.

Baschat, A.A. (2004). “Pathophysiology of fetal growth restriction: implications for diagnosis and surveillance”. Obstetrical & Gynecological Survey, 59(8), 617-627.

Wardlaw, T. (2004). Low Birthweight: Country, Regional and Global Estimates.

Romo, A.; Carceller, R.; Tobajas, J. (2009). “Intrauterine growth retardation (IUGR): epidemiology and etiology”. Pediatric Endocrinology Reviews, 6(Suppl. 3), 332-336.

Mandruzzato, G.; Antsaklis, A.; Botet, F.; Chervenak, F.A.; Figueras, F.; Grunebaum, A.; et al. (2008). “Intrauterine restriction (IUGR)”. Journal of Perinatal Medicine, 36(4), 277-281.

Rosenberg, A. (2008). “The IUGR Newborn”. Seminars in Perinatology, 32(3), 219-224.

Sehested, L.T.; Pedersen, P. (2014). “Prognosis and risk factors for intrauterine growth retardation”. Danish Medical Journal, 61(4).

Check, J.; Gotteiner, N.; Liu, X.; Su, E.; Porta, N.; Steinhorn, R.; et al. (2013). “Fetal growth restriction and pulmonary hypertension in premature infants with bronchopulmonary dysplasia”. Journal of Perinatology, 33(7), 553-557.

Murki, S.; Sharma, D. (2014). “Intrauterine Growth Retardation - A Review Article”. Journal of Neonatal Biology, 3(3).

Ramenghi, L.A.; Martinelli, A.; De Carli, A.; Brusati, V.; Mandia, L.; Fumagalli, M.; et al. (2011). “Cerebral maturation in IUGR and appropriate for gestational age preterm babies”. Reproductive Sciences, 18(5), 469-475.

Figueras, F.; Cruz-Martínez, R.; Sanz-Cortés, M.; Arranz, A.; Illa, M.; Botet, F.; et al. (2011). “Neurobehavioral outcomes in preterm, growth-restricted infants with and without prenatal advanced signs of brain-sparing”. Ultrasound in Obstetrics & Gynecology, 38, 288-294.

David J. P. Barker (2004). “The developmental origins of adult disease”. Journal of the American College of Nutrition, 23(6 Suppl.), 588S-595S.

Thorn, S.R.; Rozance, P.J.; Brown, L.D.; Hay, W.W. Jr. (2011). “The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes”. Seminars in Reproductive Medicine, 29(3), 225-236.

Grisaru-Granovsky, S.; Reichman, B.; Lerner-Geva, L.; Boyko, V.; Hammerman, C.; Samueloff, A.; et al. (2012). “Mortality and morbidity in preterm small-for-gestational-age infants”. American Journal of Obstetrics and Gynecology, 206(2), 150.e1-150.e7.

Wilcox, A.J. (1983). “Intrauterine growth retardation: beyond birthweight criteria”. Early Human Development, 8(3-4), 189-193.

Hendrix, N.; Berghella, V. (2008). “Non-Placental Causes of Intrauterine Growth Restriction”. Seminars in Perinatology, 32, 161-165.

Freeman, K.; Oakley, L.; Pollak, A.; Buffolano, W.; Petersen, E.; Semprini, A.E.; et al. (2005). “Association between congenital toxoplasmosis and preterm birth, low birthweight and small for gestational age birth”. BJOG, 112(1), 31-37.

Dall’Asta, A.; Girardelli, S.; Usman, S.; Lawin O’Brien, A.; Paramasivam, G.; Frusca, T.; et al. (2020). “Etiology and perinatal outcome of periviable fetal growth restriction associated with structural or genetic anomaly”. Ultrasound in Obstetrics & Gynecology, 55(3), 368-374.

Anandakumar, C.; Chew, S.; Wong, Y.C.; Malarvishy, G.; Po, L.U.; Ratnam, S.S. (1996). “Early Asymmetric IUGR and Aneuploidy”. Journal of Obstetrics and Gynaecology Research, 22(4), 365-370.

Meler, E.; Sisterna, S.; Borrell, A. (2019). “Genetic syndromes associated with isolated fetal growth restriction”. Prenatal Diagnosis, 40, 432-446.

Snijders, R.J.; Sherrod, C.; Gosden, C.M.; Kypros Nicolaides (1993). “Fetal growth retardation: associated malformations and chromosomal abnormalities”. American Journal of Obstetrics and Gynecology, 168(2), 547-555.

Robinson, J.S.; Moore, V.M.; Owens, J.A.; McMillen, I.C. (2000). “Origins of fetal growth restriction”. European Journal of Obstetrics & Gynecology and Reproductive Biology, 92(1), 13-19.

Scifres, C.M.; Nelson, D.M. (2009). “Intrauterine growth restriction, human placental development and trophoblast cell death”. Journal of Physiology, 587(14), 3453-3458.

Nardozza, L.M.M. y cols. (2017). “Fetal growth restriction: current knowledge”. Archives of Gynecology and Obstetrics, 295, 1061-1077.

Downloads

Published

2022-12-20

Issue

Section

Artículos

How to Cite

Amniocentesis en gestantes con fetos con restricción del crecimiento intrauterino precoz:: estudio descriptivo. (2022). Zubía, 40, 7-28. https://doi.org/10.66737/ier.zub.185

Most read articles by the same author(s)